| Artigo em revista |
- Tiago F. Outeiro; Lorraine V. Kalia; Erwan Bezard; Juan Ferrario; Chin-Hsien Lin; Mohamed Salama; David G. Standaert; et al.
"Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice". Movement Disorders
(2024): https://doi.org/10.1002/mds.29802.
10.1002/mds.29802
- Liana Shvachiy; Ângela Amaro-Leal; Filipa Machado; Isabel Rocha; Tiago F. Outeiro; Vera Geraldes. "Gender-Specific Effects
on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures". Biomedicines
(2024): https://doi.org/10.3390/biomedicines12040711.
10.3390/biomedicines12040711
- Evelini Plácido; David J. Koss; Tiago Fleming Outeiro; Patricia S. Brocardo. "Altered hippocampal doublecortin expression
in Parkinson's disease". Journal of Neurochemistry (2024): https://doi.org/10.1111/jnc.16101.
10.1111/jnc.16101
- Juan Carlos Rubilar; Tiago Fleming Outeiro; Andrés D Klein. "The lysosomal ß-glucocerebrosidase strikes mitochondria: implications
for Parkinson’s therapeutics". Brain (2024): https://doi.org/10.1093/brain/awae070.
10.1093/brain/awae070
- Avika Chopra; Anthony E. Lang; Günter Höglinger; Tiago F. Outeiro. "Towards a biological diagnosis of PD". Parkinsonism
& Related Disorders (2024): https://doi.org/10.1016/j.parkreldis.2024.106078.
10.1016/j.parkreldis.2024.106078
- Dajana Galka; Tariq T. Ali; Alexander Bast; Marie Niederleithinger; Ellen Gerhardt; Ryo Motosugi; Eri Sakata; et al. "Inhibition
of 26S proteasome activity by a-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1". Aging Cell (2024):
https://doi.org/10.1111/acel.14128.
10.1111/acel.14128
- Clara Bosbach; Luisa Maria Gatzemeier; Katja Ilme Bloch von Blottnitz; Annekatrin König; Ulf Diederichsen; Claudia Steinem;
Tiago Fleming Outeiro. "Chemical synthesis of site-selective advanced glycation end products in a-synuclein and its fragments".
Organic & Biomolecular Chemistry (2024): https://doi.org/10.1039/D4OB00225C.
10.1039/D4OB00225C
- Felipe Saceanu Leser; Mirella Araújo Ribeiro; Lucas Dalsente Romano da Silva; Renato Garcia Domingues; Tiago Fleming Outeiro;
Kevin Boyé; Eduardo Coelho Cerqueira; Fabiano Lacerda Carvalho; Phelippe do Carmo Gonçalves. "The relationship between anxiety
and COVID-19-associated isolation and lifestyle changes in the university community as a result of the SARS-CoV-2 pandemic".
Mental Health Science (2023): https://doi.org/10.1002/mhs2.48.
10.1002/mhs2.48
- Tuane C. R. G. Vieira; Caroline A. Barros; Renato Domingues; Tiago Fleming Outeiro. "PrP meets alpha-synuclein: Molecular
mechanisms and implications for disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15992.
10.1111/jnc.15992
- Andrés D. Klein; Tiago Fleming Outeiro. "Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria". Nature
Communications (2023): https://doi.org/10.1038/s41467-023-42107-7.
10.1038/s41467-023-42107-7
- Daniel Oppermann Peixoto; Reykla Ramon Bittencourt; Juciano Gasparotto; Flávio Gabriel Carazza Kessler; Pedro Ozorio Brum;
Nauana Somensi; Carolina Saibro Girardi; et al. "Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered
by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)".
Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15956.
10.1111/jnc.15956
- Manuel Flores-Leon; Tiago Fleming Outeiro. "More than meets the eye in Parkinson’s disease and other synucleinopathies: from
proteinopathy to lipidopathy". Acta Neuropathologica (2023): https://doi.org/10.1007/s00401-023-02601-0.
10.1007/s00401-023-02601-0
- Carmina C. Warth Perez Arias; Ivan Silbern; Lucas Caldi Gomes; Hannes Wartmann; Vivian Dambeck; Jonas Fanz; Lisa Neuenroth;
et al. "Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage
Parkinson's disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15924.
10.1111/jnc.15924
- Viviana Brembati; Gaia Faustini; Francesca Longhena; Tiago Fleming Outeiro; Arianna Bellucci. "Changes in a-Synuclein Posttranslational
Modifications in an AAV-Based Mouse Model of Parkinson’s Disease". International Journal of Molecular Sciences (2023):
https://doi.org/10.3390/ijms241713435.
10.3390/ijms241713435
- Evelini Plácido; Priscilla Gomes Welter; Ana Wink; Gabriela Duarte Karasiak; Tiago Fleming Outeiro; Alcir Luiz Dafre; Joana
Gil-Mohapel; Patricia S. Brocardo. "Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects
in YAC128 Mice". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612607.
10.3390/ijms241612607
- Mario Habek; Antonela Blazekovic; Kristina Gotovac Jercic; Nela Pivac; Tiago Fleming Outero; Fran Borovecki; Vesna Brinar.
"Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis". Biomedicines (2023):
https://doi.org/10.3390/biomedicines11082209.
10.3390/biomedicines11082209
- Avika Chopra; Tiago Fleming Outeiro. "Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies". Brain
(2023): https://doi.org/10.1093/brain/awad260.
10.1093/brain/awad260
- Tiago F. Outeiro; Tuane C. R. G. Vieira. "AI and protein structure and function in neurological disease: relevance to disease
management". Nature Reviews Neurology (2023): https://doi.org/10.1038/s41582-023-00840-z.
10.1038/s41582-023-00840-z
- Tiago F. Outeiro; Roy N. Alcalay; Angelo Antonini; Johannes Attems; Vincenzo Bonifati; Francisco Cardoso; Marie-Françoise
Chesselet; et al. "Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”". Movement Disorders
(2023): https://doi.org/10.1002/mds.29419.
10.1002/mds.29419
- Juciano Gasparotto; Nauana Somensi; Carolina Saibro Girardi; Reykla Ramon Bittencourt; Laura Martinewski de Oliveira; Laura
Piloneto Hoefel; Ingrid Matsubara Scheibel; et al. "Is it all the RAGE? Defining the role of the receptor for advanced glycation
end products in Parkinson's disease". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15890.
10.1111/jnc.15890
- Luisa Maria Gatzemeier; Franc Meyer; Ulf Diederichsen; Tiago Fleming Outeiro. "Chemical Synthesis of Alpha-Synuclein Proteins
via Solid-Phase Peptide Synthesis and Native Chemical Ligation". Chemistry – A European Journal (2023): https://doi.org/10.1002/chem.202300649.
10.1002/chem.202300649
- Liana Shvachiy; Ângela Amaro-Leal; Tiago F. Outeiro; Isabel Rocha; Vera Geraldes. "Intermittent Lead Exposure Induces Behavioral
and Cardiovascular Alterations Associated with Neuroinflammation". Cells (2023): https://doi.org/10.3390/cells12050818.
10.3390/cells12050818
- Luca Marsili; Jennifer Sharma; Tiago Fleming Outeiro; Carlo Colosimo. "Stem Cell Therapies in Movement Disorders: Lessons
from Clinical Trials". Biomedicines (2023): https://doi.org/10.3390/biomedicines11020505.
10.3390/biomedicines11020505
- Patrick W. Cullinane; Eduardo de Pablo Fernandez; Annekatrin König; Tiago Fleming Outeiro; Zane Jaunmuktane; Thomas T. Warner.
"Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts". Movement Disorders (2023): https://doi.org/10.1002/mds.29298.
10.1002/mds.29298
- Quesnel, Agathe; Coles, Nathan; Angione, Claudio; Dey, Priyanka; Polvikoski, Tuomo M.; Outeiro, Tiago F.; Islam, Meez; Khundakar,
Ahmad A.; Filippou, Panagiota S.. "Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy".
BMC Cancer (2023): https://publons.com/wos-op/publon/56741382/.
10.1186/S12885-023-10588-W
- Hassanzadeh, Kambiz; Morrone, Castrese; Akhtari, Keivan; Gerhardt, Ellen; Zaccagnini, Ludovica; Outeiro, Tiago Fleming; Feligioni,
Marco. "Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic". Mechanisms
of Ageing and Development (2023): https://publons.com/wos-op/publon/56816349/.
10.1016/J.MAD.2022.111759
- Outeiro, Tiago Fleming; El-Agnaf, Omar M.. "The immune system in Parkinson's disease: From biology to diagnosis and therapeutic
targets". Neurobiology of Disease (2023): https://publons.com/wos-op/publon/56816365/.
10.1016/J.NBD.2023.105995
- Aisha M. Swaih; Carlo Breda; Korrapati V. Sathyasaikumar; Natalie Allcock; Mary E. W. Collier; Robert P. Mason; Adam Feasby;
et al. "Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane". Biomedicines (2022):
https://doi.org/10.3390/biomedicines10092294.
10.3390/biomedicines10092294
- Guaragnella, Nicoletta; Krisko, Anita; Outeiro, Tiago F.. "Editorial for the Special Issue "Adaptation, Aging, and Cell Death
in Yeast Stress Response: Models, Mechanisms and Applications"". Microorganisms (2022): https://publons.com/wos-op/publon/55548779/.
10.3390/MICROORGANISMS10061126
- Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago F.; Rocha, Isabel; Geraldes, Vera. "From Molecular to Functional Effects
of Different Environmental Lead Exposure Paradigms". Biology (2022): https://publons.com/wos-op/publon/56816352/.
10.3390/BIOLOGY11081164
- Lassen, Louise Berkhoudt; Thomsen, Maj Schneider; Basso, Elisa; Fuchtbauer, Ernst-Martin; Fuchtbauer, Annette; Outeiro, Tiago
Fleming; Jensen, Poul Henning; Moos, Torben. "Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity
in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation". Cells (2022): https://publons.com/wos-op/publon/56543926/.
10.3390/CELLS11223673
- Santos, Cleonice Creusa; Cardim-Pires, Thyago R.; Shvachiy, Liana; Fonseca-Fonseca, Luis Arturo; Munoz, Patricia; Almeida,
Aurea Maria A. N.; Costa, Ana Carla S.; et al. "JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation
of Alpha-Synuclein-Aggregated Species". Neurotoxicity Research (2022): https://publons.com/wos-op/publon/55404800/.
10.1007/S12640-022-00559-7
- Bras, Ines C.; Khani, Mohammad H.; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; van Riesen, Christoph; Urlaub, Henning;
Gollisch, Tim; Outeiro, Tiago F.. "Ectosomes and exosomes modulate neuronal spontaneous activity". Journal of Proteomics
(2022): https://publons.com/wos-op/publon/56816350/.
10.1016/J.JPROT.2022.104721
- Vasili, Eftychia; Dominguez-Meijide, Antonio; Flores-Leon, Manuel; Al-Azzani, Mohammed; Kanellidi, Angeliki; Melki, Ronald;
Stefanis, Leonidas; Outeiro, Tiago Fleming. "Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured
Cells". Molecular Neurobiology (2022): https://publons.com/wos-op/publon/52531699/.
10.1007/S12035-021-02713-2
- Ghanem, Simona S.; Majbour, Nour K.; Vaikath, Nishant N.; Ardah, Mustafa T.; Erskine, Daniel; Jensen, Nanna Moller; Fayyad,
Muneera; et al. "alpha-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded
fibril formation and toxicity". Proceedings of the National Academy of Sciences (2022): https://publons.com/wos-op/publon/55106406/.
10.1073/PNAS.2109617119
- Bras, Ines C.; Khani, Mohammad H.; Vasili, Eftychia; Moebius, Wiebke; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; et
al. "Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity". Journal
of Parkinson's Disease (2022): https://publons.com/wos-op/publon/56816361/.
10.3233/JPD-223516
- Jost, Wolfgang H.; Buhmann, Carsten; Classen, Joseph; Eggert, Karla; Kohl, Zacharias; Outeiro, Tiago; Tonges, Lars; Woitalla,
Dirk; Reichmann, Heinz. "Relevance of COMT inhibitors in the treatment of motor fluctuations". Der Nervenarzt (2022):
https://publons.com/wos-op/publon/56816360/.
10.1007/S00115-021-01237-3
- Koss, David J.; Erskine, Daniel; Porter, Andrew; Palmoski, Pawel; Menon, Hariharan; Todd, Olivia G. J.; Leite, Marta; Attems,
Johannes; Outeiro, Tiago F.. "Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy
bodies". Acta Neuropathologica Communications (2022): https://publons.com/wos-op/publon/56816353/.
10.1186/S40478-022-01403-X
- Cassotta, Manuela; Geerts, Hugo; Harbom, Lise; Outeiro, Tiago F.; Pediaditakis, Iosif; Reiner, Orly; Schildknecht, Stefan;
et al. "The Future of Parkinson?s Disease Research A New Paradigm of Human Specific Investigation Is Necessary ... and Possible
...". ALTEX (2022): https://publons.com/wos-op/publon/56816358/.
10.14573/ALTEX.2203161
- Torres-Garcia, Laura; P. Domingues, Joana M.; Brandi, Edoardo; Haikal, Caroline; Mudannayake, Janitha M.; Bras, Ines C.; Gerhardt,
Ellen; et al. "Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence
complementation". Scientific Reports (2022): https://publons.com/wos-op/publon/53553098/.
10.1038/S41598-022-06846-9
- Buratti, Fiamma A.; Boeffinger, Nicola; Garro, Hugo A.; Flores, Jesica S.; Hita, Francisco J.; do Carmo Goncalves, Phelippe;
dos Reis Copello, Federico; et al. "Aromaticity at position 39 in alpha-synuclein: A modulator of amyloid fibril assembly
and membrane-bound conformations". Protein Science (2022): https://publons.com/wos-op/publon/56816355/.
10.1002/PRO.4360
- Jordan, Kate L.; Koss, David J.; Outeiro, Tiago F.; Giorgini, Flaviano. "Therapeutic Targeting of Rab GTPases: Relevance for
Alzheimer's Disease". Biomedicines (2022): https://publons.com/wos-op/publon/56816356/.
10.3390/BIOMEDICINES10051141
- Chegao, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido-Ferreira, Mariana; Marques-Morgado, Ines; Fernandes
Gomes, Barbara; et al. "Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes".
Npj Parkinson's Disease (2022): https://publons.com/wos-op/publon/52342419/.
10.1038/S41531-022-00314-X
- Shaib, A. H.; Chouaib, A. A.; Imani, V.; Chowdhury, R.; Georgiev, S. V.; Mougios, N.; Monga, M.; et al. "Expansion microscopy
at one nanometer resolution". BioRxiv (2022): https://publons.com/wos-op/publon/56816351/.
10.1101/2022.08.03.502284
- Al-Azzani, Mohammed; Koenig, Annekatrin; Outeiro, Tiago Fleming. "Production of Recombinant Alpha-Synuclein: Still No Standardized
Protocol in Sight". Biomolecules (2022): https://publons.com/wos-op/publon/50786423/.
10.3390/BIOM12020324
- Hatton, Christopher; Ghanem, Simona S.; Koss, David J.; Abdi, Ilham Y.; Gibbons, Elizabeth; Guerreiro, Rita; Bras, Jose; et
al. "Prion-like a-synuclein pathology in the brain of infants with Krabbe disease". Brain (2022): https://publons.com/wos-op/publon/56816369/.
10.1093/BRAIN/AWAC002
- Schaffner, Samantha L.; Wassouf, Zinah; Lazaro, Diana F.; Xylaki, Mary; Gladish, Nicole; Lin, David T. S.; MacIsaac, Julia;
et al. "Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways". Human
Molecular Genetics (2022): https://publons.com/wos-op/publon/56816368/.
10.1093/HMG/DDAC104
- Thom, Tobias; Schmitz, Matthias; Fischer, Anna-Lisa; Correia, Angela; Correia, Susana; Llorens, Franc; Pique, Anna-Villar;
et al. "Cellular Prion Protein Mediates alpha-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo". Movement
Disorders (2022): https://publons.com/wos-op/publon/49855476/.
10.1002/MDS.28774
- Domingues, Renato; Sant'Anna, Ricardo; Carvalho da Fonseca, Anna Carolina; Robbs, Bruno K.; Foguel, Debora; Outeiro, Tiago
F.. "Extracellular alpha-synuclein: Sensors, receptors, and responses". Neurobiology of Disease (2022): https://publons.com/wos-op/publon/51840010/.
10.1016/J.NBD.2022.105696
- Magalhaes, Rayne S. S.; Boechat, Fernanda C.; Brasil, Aline A.; Neto, Jose R. M.; Ribeiro, Gabriela D.; Paranhos, Luan H.;
de Souza, Natalia Neves; et al. "Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1". Journal
of Cellular Biochemistry (2022): https://publons.com/wos-op/publon/56816367/.
10.1002/JCB.30317
- Queiroz, Daniela D.; Ribeiro, Thales de P.; Goncalves, Julliana M.; Mattos, Larissa M. M.; Gerhardt, Ellen; Freitas, Julia;
Palhano, Fernando L.; et al. "A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and
attenuates alpha-synuclein toxicity". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2022): https://publons.com/wos-op/publon/54121415/.
10.1016/J.BBADIS.2022.166475
- Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago; Geraldes, Vera. "Behavioral and molecular changes resulted from different
environmental lead exposures: a comparative study". Journal of Neurochemistry (2022): https://publons.com/wos-op/publon/56816366/.
- Pena-Diaz, Samuel; Pujols, Jordi; Vasili, Eftychia; Pinheiro, Francisca; Santos, Jaime; Manglano-Artunedo, Zoe; Outeiro, Tiago
F.; Ventura, Salvador. "The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple
alpha-synuclein strains". Journal of Biological Chemistry (2022): https://publons.com/wos-op/publon/54454954/.
10.1016/J.JBC.2022.101902
- Rita Rosado-Ramos; Joana Godinho-Pereira; Daniela Marques; Inês Figueira; Tiago Fleming Outeiro; Regina Menezes; Cláudia Nunes
dos Santos. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation". Molecules (2021): https://doi.org/10.3390/molecules26113353.
10.3390/molecules26113353
- Tiago Fleming Outeiro. "Emerging concepts in synucleinopathies". Acta Neuropathologica (2021): https://doi.org/10.1007/s00401-021-02290-7.
10.1007/s00401-021-02290-7
- Inês C. Brás; Tiago F. Outeiro. "Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies". Cells
10 2 (2021): 375-375. https://doi.org/10.3390/cells10020375.
10.3390/cells10020375
- Tiago F. Outeiro; Anita Krisko. "Reply to: “Parkinson's Disease and COVID-19: Do We Need to Be More Patient?”". Movement
Disorders (2021): https://doi.org/10.1002/mds.28482.
10.1002/mds.28482
- David J. Koss; Odeta Bondarevaite; Sara Adams; Marta Leite; Flaviano Giorgini; Johannes Attems; Tiago F. Outeiro. "RAB39B
is redistributed in dementia with Lewy bodies and is sequestered within aß plaques and Lewy bodies". Brain Pathology
(2021): https://doi.org/10.1111/bpa.12890.
10.1111/bpa.12890
- Tiago Fleming Outeiro. "Alpha-Synuclein Antibody Characterization: Why Semantics Matters". Molecular Neurobiology (2021):
https://doi.org/10.1007/s12035-020-02269-7.
10.1007/s12035-020-02269-7
- Koss, David J.; Bondarevaite, Odeta; Adams, Sara; Leite, Marta; Giorgini, Flaviano; Attems, Johannes; Outeiro, Tiago F.. "RAB39B
is redistributed in dementia with Lewy bodies and is sequestered within a beta plaques and Lewy bodies". Brain Pathology
(2021): https://publons.com/publon/32062536/.
10.1111/BPA.12890
- Medina, Luciana; Gonzalez-Lizarraga, Florencia; Dominguez-Meijide, Antonio; Ploper, Diego; Parrales, Valeria; Sequeira, Sabrina;
Cima-Omori, Maria-Sol; et al. "Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity". Frontiers
in Aging Neuroscience (2021): https://publons.com/wos-op/publon/34409849/.
10.3389/FNAGI.2021.635760
- Schaffner, S. L.; Wassouf, Z.; Lazaro, D. F.; Xylaki, M.; Gladish, N.; Lin, D. T. S.; MacIsaac, J.; et al. "Alpha-synuclein
induces epigenomic dysregulation of glutamate signaling and locomotor pathways". BioRxiv (2021): https://publons.com/wos-op/publon/56816363/.
10.1101/2021.06.12.448150
- Flores-Leon, Manuel; Lazaro, Diana F.; Shvachiy, Liana; Krisko, Anita; Outeiro, Tiago F.. "In silico analysis of the aggregation
propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies". Biochimica et Biophysica Acta (BBA)
- Proteins and Proteomics (2021): https://publons.com/wos-op/publon/56816364/.
10.1016/J.BBAPAP.2021.140693
- Popova, Blagovesta; Wang, Dan; Paetz, Christina; Akkermann, Dagmar; Lazaro, Diana F.; Galka, Dajana; Kolog Gulko, Miriam;
et al. "DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of alpha-synuclein toxicity and oligomerization". PLOS Genetics
(2021): https://publons.com/wos-op/publon/35817065/.
10.1371/JOURNAL.PGEN.1009407
- Jacinto, Sandra; Guerreiro, Patricia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria Joao; Grazina, Manuela;
Rego, Ana Cristina; Outeiro, Tiago F.. "MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile". Frontiers
in Cellular Neuroscience (2021): https://publons.com/wos-op/publon/30853828/.
10.3389/FNCEL.2021.641264
- Erskine, Daniel; Koss, David; Walker, Lauren; Outeiro, Tiago; Attems, Johannes. "Lipid metabolism alterations are associated
with alpha-synuclein pathology in Lewy body dementia". Neuropathology and Applied Neurobiology (2021): https://publons.com/wos-op/publon/48287854/.
- Popova, Blagovesta; Wang, Dan; Rajavel, Abirami; Dhamotharan, Karthikeyan; Lazaro, Diana F.; Gerke, Jennifer; Uhrig, Joachim
F.; et al. "Identification of Two Novel Peptides That Inhibit alpha-Synuclein Toxicity and Aggregation". Frontiers in Molecular
Neuroscience (2021): https://publons.com/wos-op/publon/46047996/.
10.3389/FNMOL.2021.659926
- Oliveira, Luis M. A.; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal
A.; et al. "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease". Npj Parkinson's
Disease (2021): https://publons.com/wos-op/publon/49756374/.
10.1038/S41531-021-00203-9
- Wong-Guerra, Maylin; Montano-Peguero, Yanay; Ramirez-Sanchez, Jeney; Jimenez-Martin, Javier; Arturo Fonseca-Fonseca, Luis;
Hernandez-Ensenat, Daniela; Nonose, Yasmine; et al. "JM-20 treatment prevents neuronal damage and memory impairment induced
by aluminum chloride in rats". NeuroToxicology (2021): https://publons.com/wos-op/publon/49349605/.
10.1016/J.NEURO.2021.08.017
- Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich,
Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy
(2021): https://publons.com/wos-op/publon/34779767/.
10.1080/15548627.2020.1797280
- Koss, David J.; Campesan, Susanna; Giorgini, Flaviano; Outeiro, Tiago F.. "Dysfunction of RAB39B-Mediated Vesicular Trafficking
in Lewy Body Diseases". Movement Disorders (2021): https://publons.com/wos-op/publon/46254551/.
10.1002/MDS.28605
- Dominguez-Meijide, Antonio; Parrales, Valeria; Vasili, Eftychia; Gonzalez-Lizarraga, Florencia; Konig, Annekatrin; Lazaro,
Diana F.; Lannuzel, Annie; et al. "Doxycycline inhibits alpha -synuclein-associated pathologies in vitro and in vivo". Neurobiology
of Disease (2021): https://publons.com/wos-op/publon/36312904/.
10.1016/J.NBD.2021.105256
- Miranda, Hugo Vicente; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira,
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- Nakhjavani, M.; Morteza, A.; Khajeali, L.; Esteghamati, A.; Khalilzadeh, O.; Asgarani, F.; Outeiro, T.F.. "Increased serum
HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones 15 6 (2010): 959-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149434868&partnerID=MN8TOARS.
10.1007/s12192-010-0204-z
- de Oliveira, R.M.; Pais, T.F.; Outeiro, T.F.. "Irtuins: Common targets in aging and in neurodegeneration". Current Drug
Targets 11 10 (2010): 1270-1280. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958001297&partnerID=MN8TOARS.
- Nakhjavani, Manouchehr; Morteza, Afsaneh; Khajeali, Leila; Esteghamati, Alireza; Khalilzadeh, Omid; Asgarani, Firouzeh; Outeiro,
Tiago F.. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones (2010):
https://publons.com/publon/7283830/.
10.1007/S12192-010-0204-Z
- Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F.. "Epigenetics and Neurodegeneration: A Connection Overlooked".
Epigenetics: Mechanism, Functions and Human Effects (2010): https://publons.com/publon/12719845/.
- Outeiro, Tiago. "B07 Identification of protein interaction partners for kynurenine 3-monooxygenase, a candidate therapeutic
target for Huntington's disease". Journal of Neurology, Neurosurgery & Psychiatry (2010): https://publons.com/publon/9713564/.
10.1136/JNNP.2010.222596.7
- Outeiro, Tiago. "The sour side of neurodegenerative disorders: the effects of protein glycation". The Journal of Pathology
(2010): https://publons.com/publon/8811201/.
10.1002/PATH.2682
- Outeiro, Tiago. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial
dysfunction in Parkinson's disease models". Disease Models & Mechanisms (2010): https://publons.com/publon/9713562/.
10.1242/DMM.004267
- Outeiro, Tiago. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy
patients using FT-ICR high-resolution MS". Proteomics – Clinical Applications (2010): https://publons.com/publon/9713563/.
10.1002/PRCA.200900118
- Outeiro, Tiago. "Simple is good: yeast models of neurodegeneration". FEMS Yeast Research (2010): https://publons.com/publon/9713559/.
10.1111/J.1567-1364.2010.00649.X
- Outeiro, Tiago. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences
(2010): https://publons.com/publon/9713566/.
10.1016/J.TIBS.2010.05.007
- Outeiro, Tiago. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders
- Drug Targets (2010): https://publons.com/publon/9713560/.
- Outeiro, Tiago. "Drug discovery for CNS disorders: from bench to bedside". CNS and Neurological Disorders - Drug Targets
(2010): https://publons.com/publon/9713556/.
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Machado; et al. "Synphilin-1 Enhances alpha-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death
in a Sir2-Dependent Manner". Plos One (2010): https://publons.com/publon/5601618/.
10.1371/JOURNAL.PONE.0013700
- Outeiro, T.F.; Ferreira, J.. "Current and future therapeutic strategies for Parkinson's disease". Current Pharmaceutical
Design 15 34 (2009): 3968-3976. http://www.scopus.com/inward/record.url?eid=2-s2.0-70649115523&partnerID=MN8TOARS.
10.2174/138161209789649321
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analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry". Amyloid
16 4 (2009): 201-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-73349118440&partnerID=MN8TOARS.
10.3109/13506120903421561
- Outeiro TF; Klucken J; Bercury K; Tetzlaff J; Putcha P; Oliveira LM; Quintas A; McLean PJ; Hyman BT. "Dopamine-induced conformational
changes in alpha-synuclein.". (2009): http://europepmc.org/abstract/med/19730729.
10.1371/journal.pone.0006906
- Outeiro, Tiago. "Dopamine-Induced Conformational Changes in Alpha-Synuclein". Plos One (2009): https://publons.com/publon/9713568/.
10.1371/JOURNAL.PONE.0006906
- Outeiro, Tiago. "Intracellular signaling - cellular models to investigate alpha-synuclein function and dysfunction". Journal
of Neurochemistry (2009): https://publons.com/publon/9713573/.
- Oldriska, Marques; Oliveira Rita, M.; Ferreira, Moita Luis; Fleming, Outeiro Tiago. "Sirtuins as a link between ageing and
neurodegeneration". New Trends in Alzheimer and Parkinson Related Disorders: ADPD (2009): https://publons.com/wos-op/publon/12263479/.
- Outeiro, T.F.. "From mad cows to neurotic yeast: Novel molecular approaches to understand neurodegeneration". Microscopy
and Microanalysis 14 SUPPL. 3 (2008): 105-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349095634&partnerID=MN8TOARS.
10.1017/S143192760808954X
- Tetzlaff, J.E.; Putcha, P.; Outeiro, T.F.; Ivanov, A.; Berezovska, O.; Hyman, B.T.; McLean, P.J.. "CHIP targets toxic a-synuclein
oligomers for degradation". Journal of Biological Chemistry 283 26 (2008): 17962-17968. http://www.scopus.com/inward/record.url?eid=2-s2.0-49649125680&partnerID=MN8TOARS.
10.1074/jbc.M802283200
- Outeiro, T.F.; Marques, O.; Kazantsev, A.. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica
Acta - Molecular Basis of Disease 1782 6 (2008): 363-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-43749121572&partnerID=MN8TOARS.
10.1016/j.bbadis.2008.02.010
- Outeiro TF; Putcha P; Tetzlaff JE; Spoelgen R; Koker M; Carvalho F; Hyman BT; McLean PJ. "Correction: Formation of Toxic Oligomeric
?-Synuclein Species in Living Cells.". (2008): http://europepmc.org/abstract/PMC/PMC2556498.
- Mollenhauer, B.; Cullen, V.; Kahn, I.; Krastins, B.; Outeiro, T.F.; Pepivani, I.; Ng, J.; et al. "Direct quantification of
CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology
213 2 (2008): 315-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-49449105990&partnerID=MN8TOARS.
10.1016/j.expneurol.2008.06.004
- Fleming, J.; Outeiro, T.F.; Slack, M.; Lindquist, S.L.; Bulawa, C.E.. "Detection of Compounds That Rescue Rab1-Synuclein Toxicity".
Methods in Enzymology 439 (2008): 339-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549104669&partnerID=MN8TOARS.
10.1016/S0076-6879(07)00425-9
- Outeiro TF; Kazantsev A. "Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies.". (2008): http://europepmc.org/abstract/med/19787096.
- Outeiro, T.F.; Kazantsev, A.. "Drug targeting of a-synuclein oligomerization in synucleinopathies". Perspectives in Medicinal
Chemistry 2008 2 (2008): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953408910&partnerID=MN8TOARS.
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toxic oligomeric a-synuclein species in living cells". PLoS ONE 3 4 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-44849125207&partnerID=MN8TOARS.
10.1371/journal.pone.0001867
- Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. "Yeast as a model for studying human neurodegenerative disorders". Biotechnology
Journal 3 3 (2008): 325-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549104948&partnerID=MN8TOARS.
10.1002/biot.200700217
- Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. "Erratum: Yeast as a model for studying human neurodegenerative disorders
(Biotechnology Journal (2008) vol. 3 (325-338))". Biotechnology Journal 3 3 (2008): 421-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549148358&partnerID=MN8TOARS.
10.1002/biot.421
- Kazantsev, A. G.; Outeiro, T. F.; Amore, A. M.; Pallos, J.; Kontopoulos, E.; Atmann, S.; Kufareva, I.; et al. "Development
small molecule inhibitors of deacetylasee sirtuin 2 for treatment aggregate-associated neurodegenerative diseases". Journal
of Neurochemistry (2008): https://publons.com/publon/9713450/.
- Outeiro, Tiago. "CHIP Targets Toxic a-Synuclein Oligomers for Degradation". Journal of Biological Chemistry (2008):
https://publons.com/publon/9713443/.
10.1074/JBC.M802283200
- Outeiro, Tiago. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration".
Experimental Neurology (2008): https://publons.com/publon/6146162/.
10.1016/J.EXPNEUROL.2008.06.004
- Outeiro, Tiago Fleming; Putcha, Preeti; Tetzlaff, Julie E.; Spoelgen, Robert; Koker, Mirjam; Carvalho, Filipe; Hyman, Bradley
T.; McLean, Pamela J.. "Formation of Toxic Oligomeric alpha-Synuclein Species in Living Cells". Plos One (2008): https://publons.com/publon/9713571/.
10.1371/JOURNAL.PONE.0001867
- Outeiro, Tiago Fleming; Marques, Oldriska; Kazantsev, Aleksey. "Therapeutic role of sirtuins in neurodegenerative disease".
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2008): https://publons.com/publon/9713454/.
10.1016/J.BBADIS.2008.02.010
- Tiago Outeiro. "Drug Targeting of a-Synuclein Oligomerization in Synucleinopathies". Perspectives in Medicinal Chemistry
(2008): https://publons.com/publon/9713570/.
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et al. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein
in mouse substantia nigra". Journal of Neurochemistry 100 6 (2007): 1449-1457. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847699408&partnerID=MN8TOARS.
10.1111/j.1471-4159.2006.04310.x
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Neurology 14 1 (2007): 15-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847188168&partnerID=MN8TOARS.
10.1016/j.spen.2006.11.005
- Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. "Protein aggregation disorders". Neurobiology of Disease (2007): 111-123.
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10.1016/B978-012088592-3/50012-8
- Grammatopoulos, T.N.; Outeiro, T.F.; Hyman, B.T.; Standaert, D.G.. "Angiotensin II protects against a-synuclein toxicity and
reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications 363 3 (2007): 846-851. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848821185&partnerID=MN8TOARS.
10.1016/j.bbrc.2007.09.043
- Outeiro, T.F.; Kontopoulos, E.; Altmann, S.M.; Kufareva, I.; Strathearn, K.E.; Amore, A.M.; Volk, C.B.; et al. "Sirtuin 2
inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease". Science 317 5837 (2007): 516-519.
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10.1126/science.1143780
- Outeiro, T.F.; Grammatopoulos, T.N.; Altmann, S.; Amore, A.; Standaert, D.G.; Hyman, B.T.; Kazantsev, A.G.. "Pharmacological
inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models". Biochemical
and Biophysical Research Communications 357 3 (2007): 596-602. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247549725&partnerID=MN8TOARS.
10.1016/j.bbrc.2007.03.163
- Outeiro, Tiago. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease
in vitro models". Biochemical and Biophysical Research Communications (2007): https://publons.com/publon/9713461/.
10.1016/J.BBRC.2007.03.163
- Outeiro, Tiago. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression
of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry (2007): https://publons.com/publon/9713460/.
10.1111/J.1471-4159.2006.04310.X
- Outeiro, Tiago. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical
and Biophysical Research Communications (2007): https://publons.com/publon/9713449/.
10.1016/J.BBRC.2007.09.043
- Outeiro, Tiago Fleming; Kontopoulos, Eirene; Altmann, Stephen M.; Kufareva, Irina; Strathearn, Katherine E.; Amore, Allison
M.; Volk, Catherine B.; et al. "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease".
Science (2007): https://publons.com/publon/9713462/.
10.1126/SCIENCE.1143780
- Outeiro TF. "A bridge from Portugal to the States.". (2006): http://europepmc.org/abstract/med/17001768.
- Outeiro, T.F.. "A bridge from Portugal to the States.". Nature. 443 7107 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33749364368&partnerID=MN8TOARS.
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of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National
Academy of Sciences of the United States of America 103 11 (2006): 4246-4251. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645235438&partnerID=MN8TOARS.
10.1073/pnas.0511256103
- Outeiro, T.F.; Giorgini, F.. "Yeast as a drug discovery platform in Huntington's and Parkinson's diseases". Biotechnology
Journal 1 3 (2006): 258-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749009306&partnerID=MN8TOARS.
10.1002/biot.200500043
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proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications
351 3 (2006): 631-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751216491&partnerID=MN8TOARS.
10.1016/j.bbrc.2006.10.085
- Klucken, J.; Outeiro, T.F.; Nguyen, P.; McLean, P.J.; Hyman, B.T.. "Detection of novel intracellular a-synuclein oligomeric
species by fluorescence lifetime imaging". FASEB Journal 20 12 (2006): 2050-2057. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750117120&partnerID=MN8TOARS.
10.1096/fj.05-5422com
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formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences
(2006): https://publons.com/publon/9713442/.
10.1073/PNAS.0511256103
- Outeiro, Tiago. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and
Biophysical Research Communications (2006): https://publons.com/publon/9713459/.
10.1016/J.BBRC.2006.10.085
- Outeiro, Tiago. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". The
FASEB Journal (2006): https://publons.com/publon/9713457/.
10.1096/FJ.05-5422COM
- Lindquist, S.; Fraenkel, E.; Outeiro, T.; Gitler, A.; Su, J.; Cashikar, A.; Jagadish, S.. "Yeast cells as a discovery platform
for neurodegenerative disease". Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science) 3500
(2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-26444497156&partnerID=MN8TOARS.
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Biology, Proceedings (2005): https://publons.com/publon/9713456/.
10.1007/11415770_8
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alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.". (2004):
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10.1385/JMN:23:1-2:023
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10.1385/JMN:23:1-2:049
- Derkatch, I.L.; Uptain, S.M.; Outeiro, T.F.; Krishnan, R.; Lindquist, S.L.; Liebman, S.W.. "Effects of Q/N-rich, polyQ, and
non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings
of the National Academy of Sciences of the United States of America 101 35 (2004): 12934-12939. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444312783&partnerID=MN8TOARS.
10.1073/pnas.0404968101
- Outeiro, T.F.; Muchowski, P.J.. "Molecular genetics approaches in yeast to study amyloid diseases". Journal of Molecular
Neuroscience 23 1-2 (2004): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669436&partnerID=MN8TOARS.
- Rochet, J.-C.; Outeiro, T.F.; Conway, K.A.; Ding, T.T.; Volles, M.J.; Lashuel, H.A.; Bieganski, R.M.; Lindquist, S.L.; Lansbury
Jr., P.J.. "Interactions among a-synuclein, dopamine, and biomembranes: Some clues for understanding neurodegeneration in
Parkinson's disease". Journal of Molecular Neuroscience 23 1-2 (2004): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344641972&partnerID=MN8TOARS.
- Da Cruz E Silva, E.F.; Outeiro, T.F.; Da Cruz E Silva, O.A.B.. "Symposium on novel therapeutic opportunities for neurodegenerative
disease". Journal of Molecular Neuroscience 23 1-2 (2004): 1-2. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892653827&partnerID=MN8TOARS.
10.1385/JMN:23:1-2:001
- Outeiro, Tiago. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast
and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences (2004): https://publons.com/publon/9713441/.
10.1073/PNAS.0404968101
- Willingham, S.; Outeiro, T.F.; DeVit, M.J.; Lindquist, S.L.; Muchowski, P.J.. "Yeast Genes that Enhance the Toxicity of a
Mutant Huntingtin Fragment or a-Synuclein". Science 302 5651 (2003): 1769-1772. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345189365&partnerID=MN8TOARS.
10.1126/science.1090389
- Outeiro, T.F.; Lindquist, S.. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science
302 5651 (2003): 1772-1775. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345189364&partnerID=MN8TOARS.
10.1126/science.1090439
- Resende, C.G.; Outeiro, T.F.; Sands, L.; Lindquist, S.; Tuite, M.F.. "Prion protein gene polymorphisms in Saccharomyces cerevisiae".
Molecular Microbiology 49 4 (2003): 1005-1017. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041563922&partnerID=MN8TOARS.
10.1046/j.1365-2958.2003.03608.x
- Resende, CG; Outeiro, TF; Sands, L; Lindquist, S; Tuite, MF. "Prion protein gene polymorphisms in Saccharomyces cerevisiae".
Molecular Microbiology (2003): https://publons.com/publon/9713444/.
10.1046/J.1365-2958.2003.03608.X
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10.1126/SCIENCE.1090439
- Outeiro, Tiago. "Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein". Science (2003):
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10.1126/SCIENCE.1090389
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